Mapping brain circuits using advanced X-ray imaging techniques
Official title: Brain-wide Neuronal Circuit Mapping with X-ray Nano-Holography
Funded at Yale University · NIH-10914312 · Data updated 2026-11-12
This study is exploring new X-ray imaging techniques to create clear pictures of brain connections, helping us understand how these circuits affect decision-making, which could lead to better treatments for neurological conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $212,126 |
| NIH project number | 5R00EB032217-04 |
| Project ID | NIH-10914312 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions that affect decision-making and sensory processing.
✕Less likely to help
Patients with conditions unrelated to brain circuitry or those who do not have neurological disorders may not benefit from this research.
What this research studies
This research aims to develop cutting-edge X-ray imaging technologies to create detailed maps of neuronal circuits in the brain. By utilizing a powerful synchrotron source, the study will enhance imaging resolution to visualize connections between neurons over large areas of the brain. The approach combines non-destructive imaging with traditional methods to ensure accuracy and will focus on understanding how specific brain circuits contribute to decision-making processes. Patients may benefit from insights gained about brain function and potential treatments for neurological conditions.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain function and developing new treatments for neurological disorders.
How similar studies have gone: Other research has shown success in mapping brain circuits using advanced imaging techniques, indicating a promising avenue for this novel approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Kuan, Aaron — Yale University
- Study coordinator: Kuan, Aaron
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.