Mapping brain circuits using a special virus to understand neuron connections.
BRAIN CONNECTS: Synaptic resolution whole-brain circuit mapping of molecularly defined cell types using a barcoded rabies virus
['FUNDING_U01'] · STANFORD UNIVERSITY · NIH-11159346
This study is exploring a new way to create a detailed map of how brain cells connect and communicate with each other, which could help us understand how the brain works and how to better treat brain disorders.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11159346 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new method to map the connections between neurons in the brain at a very detailed level. By using a barcoded rabies virus, researchers aim to create a comprehensive map of synaptic connections and understand how different types of neurons interact. The approach combines advanced techniques like single-cell transcriptomics and spatial transcriptomics to link molecular characteristics of neurons with their physical connections in the brain. This could lead to a better understanding of brain function and disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions or those interested in the underlying mechanisms of brain function.
Not a fit: Patients with conditions unrelated to brain connectivity or those not willing to participate in experimental procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights into brain connectivity that may lead to new treatments for neurological disorders.
How similar studies have performed: Previous research using similar high-throughput mapping techniques has shown promising results, indicating potential for success in this novel approach.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOLIAS, ANDREAS — STANFORD UNIVERSITY
- Study coordinator: TOLIAS, ANDREAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.