Mapping brain circuits that connect subcortical areas to the frontal cortex
Comprehensively map the mesoscale thalamic circuits that route subcortical inputs to frontal cortex
This study is looking at how different parts of the brain talk to the frontal cortex, which helps us make decisions and remember things, to better understand how these connections affect our behavior.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Allen Institute NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11009584 on NIH RePORTER |
What this research studies
This research investigates how different brain regions communicate with the frontal cortex, which is crucial for decision-making and memory. By mapping the circuits that connect the thalamus, a central hub in the brain, to various subcortical inputs, the study aims to understand how these connections influence behavior. The researchers will use advanced imaging techniques and viral tracing methods to create detailed maps of these neural pathways. This comprehensive approach will help clarify the role of these circuits in cognitive functions and disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive disorders or related neurological conditions.
Not a fit: Patients with purely sensory disorders or those not experiencing cognitive issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of cognitive disorders by revealing how brain circuits function.
How similar studies have performed: Previous research has shown success in mapping brain circuits, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Allen Institute — Seattle, United States (Active)
Researchers
- Principal investigator: Murphy, Gabe J — Allen Institute
- Study coordinator: Murphy, Gabe J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.