Mapping brain changes related to Alzheimer's disease and risk factors
Official title: Core D: Integrated Computational Analysis Core
Funded at Columbia University Health Sciences · NIH-10935937 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease affects the brain by creating detailed maps of brain cells, and it's for people with and without Alzheimer's to help us better understand the disease and its risk factors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $906,089 |
| NIH project number | 5U19AG074862-02 |
| Project ID | NIH-10935937 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals diagnosed with Alzheimer's disease as well as healthy individuals for comparative analysis.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research investigates how changes associated with Alzheimer's disease are connected to various risk factors, such as age and protein aggregates, by creating detailed maps of brain tissue at the cellular level. It involves analyzing imaging and genomic data to understand how the arrangement of different cell types in the brain is affected by these changes. The project will utilize advanced computational methods to process and interpret this data, providing insights into the underlying mechanisms of Alzheimer's disease. Patients with and without Alzheimer's will contribute to building these high-resolution maps, which will enhance our understanding of the disease.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using similar computational approaches to analyze brain pathology, indicating potential for success in this novel application.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Menon, Vilas — Columbia University Health Sciences
- Study coordinator: Menon, Vilas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.