Mapping brain changes related to Alzheimer's disease
Official title: Core C: Spatial Multiomics Core
Funded at Columbia University Health Sciences · NIH-10935935 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease affects the brain by mapping out the different types of brain cells and their functions, helping us understand how age and certain proteins might play a role in the disease, and it's for anyone interested in learning more about Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,304,574 |
| NIH project number | 5U19AG074862-02 |
| Project ID | NIH-10935935 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Alzheimer's disease, those at risk for the disease, and age-matched healthy controls.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research investigates how changes associated with Alzheimer's disease are linked to specific risk factors, such as age and protein aggregates, by creating detailed maps of brain tissue at the cellular level. The study aims to generate high-resolution spatial data that reveals how different cell types and their gene expressions are arranged in the brain of individuals with and without Alzheimer's pathology. By collaborating with various cores, the project will ensure high-quality data generation and integration, ultimately enhancing our understanding of Alzheimer's disease. This work will involve advanced imaging techniques and analysis of postmortem brain tissue from diverse age groups.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new strategies for diagnosing and treating Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using spatial multiomics approaches to understand complex diseases, indicating that this methodology could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Phatnani, Hemali — Columbia University Health Sciences
- Study coordinator: Phatnani, Hemali
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.