Mapping brain changes related to Alzheimer's disease
Core C: Spatial Multiomics Core
['FUNDING_OTHER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10935935
This study is looking at how Alzheimer's disease affects the brain by mapping out the different types of brain cells and their functions, helping us understand how age and certain proteins might play a role in the disease, and it's for anyone interested in learning more about Alzheimer's.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10935935 on ClinicalTrials.gov |
What this research studies
This research investigates how changes associated with Alzheimer's disease are linked to specific risk factors, such as age and protein aggregates, by creating detailed maps of brain tissue at the cellular level. The study aims to generate high-resolution spatial data that reveals how different cell types and their gene expressions are arranged in the brain of individuals with and without Alzheimer's pathology. By collaborating with various cores, the project will ensure high-quality data generation and integration, ultimately enhancing our understanding of Alzheimer's disease. This work will involve advanced imaging techniques and analysis of postmortem brain tissue from diverse age groups.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Alzheimer's disease, those at risk for the disease, and age-matched healthy controls.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new strategies for diagnosing and treating Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in using spatial multiomics approaches to understand complex diseases, indicating that this methodology could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PHATNANI, HEMALI — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: PHATNANI, HEMALI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease pathology