Mapping brain changes in a rodent model of Alzheimer's disease
Neuropathological and spatial transcriptome brain maps in Octodon degus, a natural Alzheimer's disease rodent model
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10993099
This study is looking at how Alzheimer's disease affects the brain by using a special type of rodent that shows similar signs of the disease, and it's for anyone interested in understanding more about Alzheimer's and finding new ways to treat it.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10993099 on ClinicalTrials.gov |
What this research studies
This research investigates the brain changes associated with Alzheimer's disease using the Octodon degus, a rodent that naturally exhibits traits similar to human Alzheimer's. The study aims to create detailed maps of brain structure and gene expression in these animals, particularly focusing on those that show cognitive deficits. By comparing these maps with behavioral data, the research seeks to identify new potential targets for treatment. This approach may provide insights into the mechanisms of Alzheimer's disease and help develop better therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Alzheimer's disease or those at risk of developing it, particularly older adults.
Not a fit: Patients with non-Alzheimer's forms of dementia or cognitive impairment unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the identification of new therapeutic targets for Alzheimer's disease, potentially improving treatment options for patients.
How similar studies have performed: Other research has shown success using unconventional animal models to study Alzheimer's disease, indicating that this approach has potential for meaningful insights.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARDUNO, BERNARDO MAXIMILIANO — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: GARDUNO, BERNARDO MAXIMILIANO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.