Mapping brain cell connections related to Alzheimer's disease
Develop AD Connectivity Maps with Human iPSC-Derived Brain Cells and their Use
This study is exploring how brain cells made from stem cells can help us understand Alzheimer's disease better, especially how certain genes affect it, and it’s also looking at using existing medications to find new ways to treat the disease faster for those who need it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11089370 on NIH RePORTER |
What this research studies
This research investigates how human brain cells derived from induced pluripotent stem cells (iPSCs) can be used to create connectivity maps that reveal the underlying mechanisms of Alzheimer's disease. By focusing on the genetic factors, particularly the APOE genotype, the research aims to understand how these factors influence the development and progression of Alzheimer's. The methodology includes drug repurposing, which involves using existing medications to potentially treat Alzheimer's, thereby speeding up the process of bringing effective treatments to patients. This innovative approach seeks to overcome the challenges faced in traditional drug development for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those with the APOE4 genotype.
Not a fit: Patients who do not have genetic risk factors for Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to faster and more effective treatments for Alzheimer's disease by utilizing existing medications.
How similar studies have performed: Previous research has shown promise in drug repurposing for various conditions, indicating potential success for this novel approach in Alzheimer's treatment.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Huang, Yadong — J. David Gladstone Institutes
- Study coordinator: Huang, Yadong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.