Mapping brain activity changes in Alzheimer's Disease
Brain entropy mapping in Alzheimer's Disease
This study looks at how the brain's activity changes in people with Alzheimer's Disease compared to those who are aging healthily, hoping to find early signs of the disease by examining brain scans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10867303 on NIH RePORTER |
What this research studies
This research investigates how brain entropy, or the level of disorder in brain activity, changes in individuals with Alzheimer's Disease (AD) compared to healthy aging. By analyzing existing brain imaging data, the study aims to identify patterns that could indicate early signs of AD before symptoms appear. The researchers will focus on a specific measure called functional brain entropy (fBEN) to understand how brain function deteriorates as the disease progresses. This approach could help bridge the gap between the biological changes in the brain and the clinical symptoms experienced by patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults, particularly those who are experiencing mild cognitive impairment or are at risk for Alzheimer's Disease.
Not a fit: Patients with advanced Alzheimer's Disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of Alzheimer's Disease, allowing for timely interventions and better management of the condition.
How similar studies have performed: Previous research using similar brain imaging techniques has shown promise in identifying early markers of Alzheimer's Disease, suggesting that this approach could be effective.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Wang, Ze — University of Maryland Baltimore
- Study coordinator: Wang, Ze
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.