Mapping blood vessels in the brain's entorhinal cortex to understand Alzheimer's disease
Identifying microscopic vasculature within entorhinal cortex in healthy aging and its proximity to pathology profiles in Alzheimer's disease
This study is looking at how tiny blood vessels in a part of the brain called the entorhinal cortex might be linked to Alzheimer's disease, using special imaging and tissue tests to see how blood flow affects brain health and memory loss.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10657895 on NIH RePORTER |
What this research studies
This research investigates the relationship between microscopic blood vessels in the entorhinal cortex and the pathology of Alzheimer's disease. By using advanced imaging techniques and histological analysis, the study aims to identify specific vascular territories that may contribute to neuronal death associated with dementia. The researchers will utilize high-resolution MRI and validate their findings with tissue staining to better understand how cerebrovascular health impacts Alzheimer's progression. This approach seeks to connect neuroimaging data with actual brain tissue characteristics, providing insights into the disease's mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline related to aging.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of Alzheimer's disease and potentially new strategies for early diagnosis and treatment.
How similar studies have performed: While the specific approach of mapping microvascular patterns in the entorhinal cortex is novel, similar studies have shown success in linking vascular health to neurodegenerative diseases.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Augustinack, Jean — Massachusetts General Hospital
- Study coordinator: Augustinack, Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.