Mapping blood vessels in the brain's entorhinal cortex to understand Alzheimer's disease

Who could benefit from this research

What this research studies

This research investigates the relationship between microscopic blood vessels in the entorhinal cortex and the pathology of Alzheimer's disease. By using advanced imaging techniques and histological analysis, the study aims to identify specific vascular territories that may contribute to neuronal death associated with dementia. The researchers will utilize high-resolution MRI and validate their findings with tissue staining to better understand how cerebrovascular health impacts Alzheimer's progression. This approach seeks to connect neuroimaging data with actual brain tissue characteristics, providing insights into the disease's mechanisms.

Why it matters

Where this research is happening

• Massachusetts General Hospital
  Boston, United States Active

Researchers

• Principal investigator: Augustinack, Jean — Massachusetts General Hospital
• Study coordinator: Augustinack, Jean

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.