Mapping blood neutrophils to assess organ health
High dimensional atlas of circulating neutrophils as reporters of solid organ functional status
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10893504
This study is looking at how certain immune cells in your blood can help us spot problems with your organs early on, even before you feel any symptoms, and we’d love for patients to share their blood samples to help us learn more about this connection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10893504 on ClinicalTrials.gov |
What this research studies
This research investigates how circulating neutrophils in the blood can serve as indicators of the functional status of solid organs. By analyzing these immune cells, the study aims to develop a non-invasive method to detect chronic solid organ diseases early, potentially before symptoms arise. The approach involves creating a detailed atlas of neutrophil characteristics that reflect organ health, which could lead to timely therapeutic interventions. Patients may provide blood samples to help researchers understand the relationship between neutrophil behavior and organ function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for chronic solid organ diseases, such as those with a family history of such conditions or presenting early symptoms.
Not a fit: Patients with acute organ failure or those who have already been diagnosed with advanced chronic solid organ diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enable earlier detection and treatment of chronic solid organ diseases, improving patient outcomes.
How similar studies have performed: Other research has shown promise in using immune cell profiles for disease detection, suggesting that this approach may yield valuable insights.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OKWAN-DUODU, DERICK — STANFORD UNIVERSITY
- Study coordinator: OKWAN-DUODU, DERICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease