Mapping and stimulating brain circuits to treat depression
Personalized circuit-based neuromodulation targets for depression
This study is looking at how to use a special technique called transcranial magnetic stimulation (TMS) to find and target the right areas in the brain to help people with major depression feel better, making treatments more personalized and effective for each individual.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10909930 on NIH RePORTER |
What this research studies
This research aims to explore how specific brain circuits can be identified and targeted using transcranial magnetic stimulation (TMS) to alleviate symptoms of major depression. By utilizing advanced imaging techniques, the study will map the connectivity of brain circuits and determine the most effective stimulation sites for individual patients. The approach combines psychiatric expertise with computational methods to enhance treatment efficacy and personalize care for those suffering from depression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with major depression who have not responded adequately to traditional treatments.
Not a fit: Patients with depression who are not suitable for TMS or have other underlying conditions that complicate treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients with major depression.
How similar studies have performed: Previous research has shown promising results in using targeted TMS for depression, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Siddiqi, Shan — Brigham and Women's Hospital
- Study coordinator: Siddiqi, Shan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.