Mapping and manipulating brain activity related to Alzheimer's disease in mice
Official title: Uncharted Territory: Mapping and Manipulating Cholinergic Basal Forebrain Activity in a Mouse Model of Alzheimer's Disease
Funded at Baylor College of Medicine · NIH-11030789 · Data updated 2026-11-12
This study is looking at how the loss of certain brain cells in mice affects thinking and memory in Alzheimer's disease, hoping to find new ways to help people with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $47,592 |
| NIH project number | 5F30AG076265-03 |
| Project ID | NIH-11030789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of cholinergic neurons in the basal forebrain and their degeneration in Alzheimer's disease using a mouse model. The study aims to understand how the loss of these neurons affects cognitive function and whether this degeneration occurs in a systematic way. By examining the relationship between neuron loss and cognitive deficits, the research seeks to uncover new insights into Alzheimer's disease progression and potential therapeutic targets. The approach includes advanced techniques to manipulate and map neuronal activity, providing a clearer picture of the disease's impact on the brain.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or reversing cognitive decline in Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in targeting cholinergic systems in Alzheimer's models, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Belfort, Benjamin — Baylor College of Medicine
- Study coordinator: Belfort, Benjamin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.