Mapping and controlling brain circuits using a modified yellow fever virus
Cell Type-specific Anterograde Circuit Mapping and Functional Control by Optimizing YFV-17D Transneuronal Systems
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10505702
This study is exploring how different brain cells work together and connect, using a safe virus from the yellow fever vaccine to help scientists see and control these connections better, which could lead to new ways to understand and treat brain-related issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10505702 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how different types of neurons in the brain connect and function together. By using specially engineered viral vectors derived from the yellow fever vaccine, the researchers aim to map neuronal connections and control the activity of specific neurons. This approach allows for precise observation and manipulation of brain circuits, which could lead to new insights into brain function and potential treatments for neurological conditions. The study involves developing safer and more effective viral tools to enhance the understanding of brain circuitry.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that affect brain circuitry, such as movement disorders or cognitive impairments.
Not a fit: Patients with conditions unrelated to brain circuitry or those who do not have access to the required experimental interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in treating neurological disorders by providing new ways to manipulate and understand brain function.
How similar studies have performed: Previous research using viral vectors for mapping and manipulating brain circuits has shown promising results, indicating that this approach has potential for success.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XU, WEI — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: XU, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.