Mapping and analyzing senescent cells in lung and heart tissues
TriState SenNET (Lung and Heart) Tissue Map and Atlas consortium
This study is looking at old cells in the lungs and hearts of people to understand how they contribute to age-related diseases, with the goal of finding new treatments to help improve health as we get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10923841 on NIH RePORTER |
What this research studies
This research investigates the accumulation of senescent cells in human lung and heart tissues, which are linked to age-related diseases. By analyzing these tissues, the study aims to create a detailed map of the unique molecular characteristics of senescent cells, similar to how tumors are studied. The approach involves using advanced techniques like ATAC sequencing to understand the specific drivers of senescence and their implications for health. This knowledge could help in developing targeted therapies for age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues, particularly those related to lung and heart function.
Not a fit: Patients with acute conditions unrelated to aging or those who are not experiencing age-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for age-related diseases affecting the lungs and heart.
How similar studies have performed: Previous research has shown promise in understanding senescence in animal models, but this approach in human tissues is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Finkel, Toren — University of Pittsburgh at Pittsburgh
- Study coordinator: Finkel, Toren
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.