Mapping and analyzing brain samples from Alzheimer's patients
3D Reconstruction and Analysis of Alzheimer's Patient Biopsy Samples to Map and Quantify Hallmarks of Pathogenesis and Vulnerability
This study is looking at brain samples from people with Alzheimer's Disease using special 3D imaging to find important details about how the disease affects brain cells, which could help us understand what makes them vulnerable.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10764298 on NIH RePORTER |
What this research studies
This research focuses on using advanced 3D electron microscopy to analyze brain biopsy samples from patients with Alzheimer's Disease. By reconstructing and examining these samples, the team aims to uncover critical structural details related to the disease's progression, including the presence of neurofibrillary tangles and amyloid plaques. The methodology involves high-throughput imaging techniques to explore brain cell structures and their connections in greater detail than previously possible. This could lead to a better understanding of the cellular vulnerabilities associated with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease, particularly those whose brain biopsy samples are part of the study.
Not a fit: Patients without a diagnosis of Alzheimer's Disease or those who have not undergone brain biopsy procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of Alzheimer's Disease and potentially inform new therapeutic strategies.
How similar studies have performed: Previous research using 3D electron microscopy has shown promise in understanding neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Ellisman, Mark H — University of California, San Diego
- Study coordinator: Ellisman, Mark H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.