Mapping aging (senescent) cells in kidney, fat, pancreas, placenta, and skin
The KAPP-Sen Tissue Mapping Center Collaborative
This project will map where aging (senescent) cells live and how they differ across healthy human organs to help researchers better understand aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-11177702 on NIH RePORTER |
What this research studies
From the patient's viewpoint, researchers will collect tissue samples from consenting donors at several medical centers and analyze those samples with advanced lab and computational methods to find and describe senescent cells. The work focuses on healthy human kidney, adipose (fat), pancreas, and placenta tissues, with possible complementary skin samples. Teams across six institutions will standardize procedures, generate cellular maps, and share data to build a clear picture of how senescent cells vary by tissue and person. The goal is to create openly accessible maps and biological markers that other scientists can use to guide new treatments for age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates are people willing to donate tissue samples (for example surgical discards, biopsy donors, organ or placental donors, or healthy volunteers) at one of the participating centers.
Not a fit: People who cannot or will not provide tissue samples, or those seeking an immediate clinical treatment, are unlikely to receive direct benefit from this mapping project.
Why it matters
Potential benefit: If successful, the maps and markers could point to targets for therapies that reduce harmful senescent cells and slow tissue aging, benefiting patients with age-related conditions in the future.
How similar studies have performed: Large cell-atlas projects have successfully mapped many cell types, but detailed, multi-tissue mapping of senescent cells in healthy human organs is a newer and still-emerging area.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Kuchel, George a — University of Connecticut Sch of Med/dnt
- Study coordinator: Kuchel, George a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.