Mapping aging (senescent) cells across mouse organs over the lifespan
Official title: Spatial Mapping Senescent Cells Across the Mouse Lifespan by Multiplex Transcriptomics and Epigenomics
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-11363960 · Data updated 2026-11-12
Researchers will create detailed maps of aging (senescent) cells in key organs of male and female mice to show where these cells appear and how they change with age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $198,900 |
| NIH project number | 3U54AG079758-04S1 |
| Project ID | NIH-11363960 on NIH RePORTER |
Who could benefit from this research
✓Could help
There are no human participants or enrollment—this work uses mouse tissues, so patients cannot join this project.
✕Less likely to help
People seeking immediate treatments or wishing to enroll in a clinical trial will not directly benefit from this mouse-based foundational research.
What this research studies
This project uses advanced single-cell and spatial methods to profile gene activity and chromatin changes in brain, bone marrow, breast, colon, and liver from male and female mice at multiple ages. The team will combine in situ and tissue-dissociation multi-omic tools to produce single-cell-resolution transcriptome and epigenome maps with spatial information. Results will quantify the normal burden and locations of senescent cells across tissues and the lifespan and aim to define molecular signatures of senescence. The center will generate shared atlases and datasets to help other researchers link senescent-cell types to age-related disease mechanisms.
Why it matters
Potential benefit: If successful, these atlases could help scientists pinpoint harmful senescent cells and guide development of targeted therapies for age-related conditions.
How similar studies have gone: Previous mouse and early human research has identified senescent-cell signatures and shown promise for senolytic approaches, but comprehensive spatial single-cell atlases across multiple organs are new.
Where this research is happening
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Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Adams, Peter D. — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Adams, Peter D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.