Mapping aging-related changes in various tissues
The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC)
['FUNDING_OTHER'] · JACKSON LABORATORY · NIH-10894253
This study is looking at how aging cells affect different parts of the body, like the kidneys, fat, and heart, to help find new treatments for age-related health issues that could benefit patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JACKSON LABORATORY (nih funded) |
| Locations | 1 site (BAR HARBOR, UNITED STATES) |
| Trial ID | NIH-10894253 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how cellular senescence, a process linked to aging, affects different tissues in the body, including the kidney, adipose tissue, and heart. By using advanced mouse models, researchers will analyze the characteristics of senescent cells and their impact on chronic diseases associated with aging. The study employs cutting-edge techniques such as single-cell RNA sequencing and spatial transcriptomics to provide detailed insights into the biology of aging tissues. Patients may benefit from the findings that could lead to new treatments for age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals experiencing age-related health issues or chronic diseases.
Not a fit: Patients with acute conditions unrelated to aging or cellular senescence may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for chronic diseases associated with aging.
How similar studies have performed: Other research has shown success in understanding cellular senescence and its implications for aging, making this approach promising.
Where this research is happening
BAR HARBOR, UNITED STATES
- JACKSON LABORATORY — BAR HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROSENTHAL, NADIA A — JACKSON LABORATORY
- Study coordinator: ROSENTHAL, NADIA A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.