Mapping aging-related cellular changes in tissues
Official title: The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC)
Funded at Jackson Laboratory · NIH-11290502 · Data updated 2026-11-12
This study is looking at how our cells change as we get older by examining tissues from specially bred mice, and it aims to find out more about aging and age-related diseases to help improve ways to track and understand these changes in our health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | May 23, 2025 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $259,622 |
| NIH project number | 3U54AG079753-03S1 |
| Project ID | NIH-11290502 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related health issues or those interested in the biological aspects of aging.
✕Less likely to help
Patients who are not experiencing age-related diseases or conditions may not benefit from this research.
What this research studies
This research investigates the cellular changes associated with aging by analyzing tissues from genetically defined mouse models. The study focuses on identifying senescent cells and their characteristics in various tissues, such as lung, muscle, and ovary, to better understand the biological mechanisms of aging and age-related diseases. By using known senescence inducers and standardized environments, researchers aim to create detailed cellular maps that could lead to improved biomarkers for aging. This work is part of a larger collaborative effort to enhance our understanding of how aging affects health and disease.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for age-related diseases.
How similar studies have gone: Previous research in cellular senescence has shown promising results, indicating that this approach could yield valuable insights into aging.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Rosenthal, Nadia a — Jackson Laboratory
- Study coordinator: Rosenthal, Nadia a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.