Mapping aging cells in tissues to understand their roles in health and disease
Biological Analysis Core
This study is looking at how certain aging cells build up in our bodies and affect our health, using mice to learn more about where these cells show up in different tissues, which could help us understand their role in humans as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10908552 on NIH RePORTER |
What this research studies
This research investigates the accumulation of senescent cells (SnCs) as we age and their impact on health. By using mice as a model, the team will identify when and where these cells appear in various tissues, such as fat, muscle, liver, brain, and lungs. They will employ advanced techniques to analyze these cells at both bulk and single-cell levels, aiming to create detailed atlases that can inform future studies in humans. The findings could help clarify the balance between the beneficial and harmful roles of SnCs in the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related health issues or those interested in the biological processes of aging.
Not a fit: Patients who are not experiencing age-related conditions or are under the age of three may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for age-related diseases by targeting senescent cells.
How similar studies have performed: Previous research has shown promising results in understanding senescent cells in animal models, indicating potential for success in this approach.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Lebrasseur, Nathan K — University of Minnesota
- Study coordinator: Lebrasseur, Nathan K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.