Mapping aging cells in the body throughout life
Spatial mapping senescent cells across the mouse lifespan by multiplex transcriptomics and epigenomics
This study is looking at how old cells build up in different parts of the body as mice get older, which could help us understand age-related diseases and find new ways to manage or prevent them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10889156 on NIH RePORTER |
What this research studies
This research investigates how aging cells, known as senescent cells, accumulate in various tissues of the body as mice age. By using advanced techniques to analyze the genetic and epigenetic changes in these cells, the researchers aim to create detailed maps of where these cells are located in the brain, bone marrow, breast, colon, and liver. This work will help to better understand the role of senescent cells in age-related diseases and could lead to new insights into how to manage or prevent these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be experiencing age-related health issues.
Not a fit: Patients under the age of 65 or those without age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating age-related diseases by targeting senescent cells.
How similar studies have performed: Other research has shown promising results in understanding cellular senescence, making this approach both relevant and potentially impactful.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Adams, Peter D. — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Adams, Peter D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.