Mapping aging cells in mouse tissues to understand their role in diseases like Alzheimer's.
Midwest Murine-Tissue Mapping Center (MM-TMC)
['FUNDING_OTHER'] · UNIVERSITY OF MINNESOTA · NIH-10908548
This study is looking at special aging cells that can affect conditions like Alzheimer's, and it's trying to understand how these cells work in the body so we can find safe ways to get rid of the bad ones in people.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10908548 on ClinicalTrials.gov |
What this research studies
This research investigates the role of senescent cells, which are linked to aging and diseases such as Alzheimer's. By creating a detailed 4D atlas of these cells in various mouse tissues, including the brain, the study aims to uncover how these cells contribute to both harmful and beneficial biological processes. The research utilizes advanced techniques in cell mapping and bioinformatics to analyze the interactions between senescent cells and the immune system. Ultimately, the goal is to inform potential pharmacologic strategies for safely removing harmful senescent cells in humans.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include older adults or individuals with age-related conditions, particularly those at risk for Alzheimer's disease.
Not a fit: Patients with acute conditions unrelated to aging or Alzheimer's may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve health outcomes for aging individuals and those suffering from age-related diseases.
How similar studies have performed: Previous research has shown promising results in animal models regarding the removal of senescent cells and its effects on age-related diseases, indicating potential for success in this approach.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROBBINS, PAUL D. — UNIVERSITY OF MINNESOTA
- Study coordinator: ROBBINS, PAUL D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease