Mapping aging cells in mouse tissues
JHU-Mayo-NIA Murine Senescence Mapping Program (JMN-MSMP)
This study is looking at how aging cells behave in mice over their lives to better understand how they might affect health as we get older, using advanced techniques to track these changes in different tissues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10894300 on NIH RePORTER |
What this research studies
This research aims to create a detailed atlas of aging cells in mouse tissues throughout their lifespan. It utilizes advanced biological resources, including various strains of aging mice and a comprehensive tissue bank, to identify and analyze senescent cells. The study employs cutting-edge techniques such as single-cell sequencing and spatial transcriptomics to understand how these aging cells communicate and interact within tissues. By focusing on specific markers in blood plasma and serum, the research seeks to uncover the timeline of cellular aging and its implications for age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging and age-related diseases.
Not a fit: Patients with acute conditions unrelated to aging or cellular senescence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for age-related conditions in humans.
How similar studies have performed: Other research has shown promise in mapping cellular aging, suggesting that this approach could yield significant insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Elisseeff, Jennifer H — Johns Hopkins University
- Study coordinator: Elisseeff, Jennifer H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.