Mapping aging cells in immune and bone marrow tissues
Yale TMC for Cellular Senescence in Lymphoid Organs
This project maps aging (senescent) cells in immune tissues like bone marrow and thymus to learn how they influence health as people age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11173652 on NIH RePORTER |
What this research studies
Researchers will collect and analyze human bone marrow, thymus, and other lymphoid tissues to create detailed maps of aging cells and their surrounding tissue. They will use advanced molecular profiling, imaging, and biomarker tests to identify which cell types become senescent, where they sit, and what they secrete. The team will compare samples across ages and stress conditions to see how senescent cells change over time. All data, images, and methods will be shared so other scientists and clinicians can use the maps to guide new therapies or tissue-repair strategies.
Who could benefit from this research
Good fit: Ideal participants are people willing to donate bone marrow, thymus, or other lymphoid tissue samples, including healthy adult and older adult donors or surgical/tissue-donor participants at collaborating sites.
Not a fit: Patients seeking immediate clinical treatment or those with conditions unrelated to immune or bone marrow aging are unlikely to receive direct benefit from this mapping project.
Why it matters
Potential benefit: If successful, this work could reveal targets or signals to remove harmful senescent cells or harness beneficial ones, helping improve immune function and tissue repair with aging.
How similar studies have performed: Related tissue-atlas and cellular senescence projects have produced useful maps and biomarkers, but applying these methods specifically to human lymphoid organs is relatively new.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Fan, Rong — Yale University
- Study coordinator: Fan, Rong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.