Mapping advanced colon adenomas and their surrounding tissue to understand cancer progression
Comprehensive atlas of advanced adenomas and their surrounding primed colon: A multi-omics evaluation and clinical impact assessment
['FUNDING_OTHER'] · FRED HUTCHINSON CANCER CENTER · NIH-10926951
This study is looking at how certain growths in the colon, called adenomas, can lead to colorectal cancer, and it aims to find out which ones are more likely to become serious, so that patients can get better screening and prevention options.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10926951 on ClinicalTrials.gov |
What this research studies
This research investigates the progression of colon adenomas, which are precursors to colorectal cancer (CRC). By analyzing both the adenomas and the surrounding 'primed' colon tissue, the study aims to identify molecular signatures that differentiate between aggressive and indolent lesions. The approach involves a multi-omics evaluation, which combines various biological data types to gain a comprehensive understanding of the factors influencing adenoma progression. Patients may benefit from insights that could lead to improved screening and prevention strategies for CRC.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with diagnosed colon adenomas who are at risk for colorectal cancer.
Not a fit: Patients without any history of colon adenomas or those who have already been diagnosed with colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better predictive markers for identifying which adenomas are likely to progress to colorectal cancer, potentially improving patient outcomes.
How similar studies have performed: Other research has shown promise in using multi-omics approaches to understand cancer progression, suggesting that this methodology could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRADY, WILLIAM MALLORY — FRED HUTCHINSON CANCER CENTER
- Study coordinator: GRADY, WILLIAM MALLORY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers