Manufacture of clean, frozen Plasmodium vivax sporozoites for malaria research
Official title: Manufacture of aseptic, purified, cryopreserved Plasmodium vivax sporozoites
Funded at Sanaria, INC. · NIH-11413595 · Data updated 2026-11-12
A funded NIH project will produce aseptic, purified, and cryopreserved Plasmodium vivax sporozoites to support testing of drugs, vaccines, and diagnostics for vivax malaria.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanaria, INC. NIH-funded |
| Lab location | 1 site (Rockville, United States) |
| Project start | April 21, 2016 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,000,000 |
| NIH project number | 5U44AI124867-08 |
| Project ID | NIH-11413595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals in malaria-endemic regions or research volunteers contributing samples or data related to Pv exposure, who could benefit from improved interventions.
✕Less likely to help
Individuals not at risk for vivax malaria or not involved in Pv research activities may not directly benefit.
What this research studies
This project aims to manufacture standardized Pv sporozoites under GMP conditions so researchers can run controlled studies without relying on patient blood. By creating a reliable source of Pv sporozoites, the work supports testing of new treatments and vaccines against vivax malaria. The team has previously demonstrated infectious Pv sporozoites in humanized models and will scale up production under strict quality controls. The effort addresses a major bottleneck in Pv research, enabling comparison across interventions and faster progress toward better tools.
Why it matters
Potential benefit: If successful, patients in the future could benefit from faster development of effective drugs, vaccines, and diagnostics against vivax malaria.
How similar studies have gone: Previous work showed successful production and use of Pv sporozoites in controlled settings, with evidence of infectivity in humanized models, supporting progression to GMP-scale production.
Where this research is happening
-
Sanaria, INC.
Rockville, United States Active
Researchers
- Principal investigator: Chakravarty, Sumana — Sanaria, INC.
- Study coordinator: Chakravarty, Sumana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.