Manipulating NAD+ levels to improve kidney health after injury.
Official title: Compartment-specific manipulation of NAD+ to mitigate post-injury kidney disease.
Funded at Northwestern University at Chicago · NIH-11055784 · Data updated 2026-11-12
This study is looking at how boosting a substance called NAD+ in kidney cells might help protect older adults from damage caused by acute kidney injury, with the hope of improving their kidney health and overall well-being.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $437,973 |
| NIH project number | 1R21AG086806-01A1 |
| Project ID | NIH-11055784 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly patients who have experienced acute kidney injury.
✕Less likely to help
Patients with chronic kidney disease unrelated to acute kidney injury may not benefit from this research.
What this research studies
This research investigates how different levels of nicotinamide adenine dinucleotide (NAD+) in specific parts of kidney cells can help protect against damage caused by acute kidney injury (AKI). By understanding how NAD+ functions within kidney cells, the researchers aim to develop methods to boost its levels, potentially improving energy generation and cellular health. The study focuses on elderly patients who are particularly vulnerable to AKI and its long-term effects, such as chronic kidney disease. The approach involves exploring cytoprotective strategies that could enhance kidney function and overall health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent chronic kidney disease in patients recovering from acute kidney injury.
How similar studies have gone: Previous studies have shown promising results with NAD+ precursor supplementation in protecting kidney function, indicating potential for success in this approach.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Kapitsinou, Pinelopi P. — Northwestern University at Chicago
- Study coordinator: Kapitsinou, Pinelopi P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.