Manipulating a protein complex to improve blood vessel health
Genetic and pharmacological manipulation of HEG1-KRIT1 protein complex modulates endothelial vasoprotective functions
This study is looking at how changes in a specific protein complex can help make blood vessels healthier and reduce the risk of problems like blood clots and inflammation, which could lead to better heart health for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10902046 on NIH RePORTER |
What this research studies
This research investigates how altering the HEG1-KRIT1 protein complex can enhance the protective functions of blood vessels. By studying genetic changes in mice, the researchers aim to understand how these changes affect the expression of important proteins that help prevent blood clots and inflammation. The approach focuses on the role of specific transcription factors that are activated in response to blood flow, which may lead to better vascular health and reduced risk of conditions like atherosclerosis. Patients may benefit from insights gained about how to improve endothelial function and prevent vascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals at risk for atherosclerosis or other vascular conditions.
Not a fit: Patients with established vascular diseases or those who do not have risk factors for vascular issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating vascular diseases, improving overall cardiovascular health.
How similar studies have performed: Other research has shown promising results in manipulating similar protein complexes to improve vascular health, indicating potential for success in this approach.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Lopez-Ramirez, Miguel Alejandro — University of California, San Diego
- Study coordinator: Lopez-Ramirez, Miguel Alejandro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.