Malaria medicines that target multiple parasite stages
Optimization of antimalarials targeting multiple life stages of the parasite
Researchers are improving two new drug candidates meant to kill malaria parasites at different stages to help people at risk of or living with malaria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11143016 on NIH RePORTER |
What this research studies
You can think of this work as lab and preclinical testing to make two promising antimalarial compounds stronger and safer. The team uses computer screening, chemistry, and experiments in blood and liver parasite stages (and some animal models) to change the molecules and measure how well they work. They also study how the body absorbs and clears the compounds and look for ways the parasite might become resistant. The goal is to pick the best candidates to move into formal safety and human trials later on.
Who could benefit from this research
Good fit: Future clinical trials would likely enroll people exposed to or infected with malaria, especially in regions where the disease is common.
Not a fit: Because this is preclinical work, patients needing immediate treatment will not receive direct benefit from this grant right now.
Why it matters
Potential benefit: If successful, these drugs could offer new treatments that clear infection, block transmission, and work against drug-resistant malaria.
How similar studies have performed: Related antimalarial classes like artemisinins have proven effective, and the team's earlier compound showed activity, but these specific molecules are novel and need further testing.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Carlier, Paul R — University of Illinois at Chicago
- Study coordinator: Carlier, Paul R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.