Making TB prevention routine for people with HIV in South Africa
Prevent TB: Application of choice architecture to implement TB preventive therapy in South Africa
This project uses small changes in clinic procedures to make TB preventive treatment the default for adults living with HIV in South Africa.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11010789 on NIH RePORTER |
What this research studies
If you get HIV care at a participating clinic in South Africa, clinic workflows would be changed so TB preventive therapy becomes the usual option rather than an unusual extra step. Staff will receive prompts, altered forms, and training to reduce unnecessary tests and paperwork that delay preventive treatment. The team will track how many people start and complete preventive therapy and monitor TB cases and deaths over time. Participating clinics will be compared with others to see whether the changes increase prescribing and protection against TB.
Who could benefit from this research
Good fit: Adults living with HIV who are eligible for TB preventive therapy and who receive care at participating clinics in South Africa are the ideal candidates.
Not a fit: People who have active TB disease, serious liver problems, or who do not attend the participating clinics are unlikely to benefit from this project.
Why it matters
Potential benefit: If successful, more people living with HIV could receive and finish TB preventive therapy, lowering TB cases and deaths.
How similar studies have performed: TB preventive therapy is a proven way to reduce TB and death in people with HIV, but using choice-architecture or default-prescribing to increase TPT uptake is a newer approach with limited prior evidence.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Hoffmann, Christopher J — Johns Hopkins University
- Study coordinator: Hoffmann, Christopher J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.