Making radiation therapy more effective for glioblastoma
Exploiting cell fate transition to overcome radiation resistance in glioblastoma
This research explores new ways to make radiation treatments work better for people with glioblastoma, a serious type of brain tumor.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11124133 on NIH RePORTER |
What this research studies
Glioblastoma is a challenging brain cancer that often resists standard radiation therapy. Our team is looking into why these tumors become resistant by studying specific changes in tumor cells, especially those that act like stem cells. We've found three key areas in these cells related to their metabolism, genetics, and DNA repair that we believe we can target. The goal is to combine new drug targets with current radiation methods to make the treatment more powerful against glioblastoma.
Who could benefit from this research
Good fit: This research is focused on understanding and treating glioblastoma, so it is most relevant to adult patients diagnosed with this type of brain tumor.
Not a fit: Patients without glioblastoma or those not undergoing radiation therapy for this condition would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help glioblastoma patients respond better to radiation therapy, potentially improving their outcomes.
How similar studies have performed: Our team has pioneered some of the ideas behind this work, and new preliminary data suggests promising targets to overcome radiation resistance.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Sulman, Erik — New York University School of Medicine
- Study coordinator: Sulman, Erik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.