Making head and neck cancer models better for finding new treatments
Improving the translational value of head and neck cancer patient-in-mouse models
['FUNDING_R37'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11114051
This work aims to improve how we use patient tumor samples in laboratory models to find more effective treatments for head and neck cancer.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11114051 on ClinicalTrials.gov |
What this research studies
When patients have surgery for head and neck cancer, a small piece of their tumor can be used to create a special model, often by growing it in a mouse. These 'patient-derived models' help scientists understand how tumors grow and test new medicines. This project wants to make sure these models are as accurate and helpful as possible. We are looking at how different ways of handling the tumor samples and growing them in the lab affect the results, so that future discoveries are more reliable for patients.
Who could benefit from this research
Good fit: This research is relevant to patients with head and neck cancer whose tumor samples are used to create these laboratory models, and those who may benefit from future therapies developed using these improved models.
Not a fit: Patients not affected by head and neck cancer or those whose treatment is not informed by these specific laboratory models may not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could lead to more accurate and predictive laboratory models, speeding up the discovery of new and better treatments for head and neck cancer patients.
How similar studies have performed: While patient-derived models are commonly used, there is currently limited data on how initial handling decisions impact their accuracy, making this a novel approach to optimize their use.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIMPLE, RANDALL J. — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: KIMPLE, RANDALL J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.