Making gene editing more effective for genetic diseases
Elucidating factors that modulate mammalian DNA repair to improve genome editing
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11087638
This project helps us understand how our cells naturally fix DNA, which can make gene editing treatments for genetic diseases more precise and effective.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11087638 on ClinicalTrials.gov |
What this research studies
Gene editing, using tools like CRISPR, holds great promise for treating many inherited conditions. These treatments rely on how our cells naturally repair their DNA, but this repair process can vary, making gene editing less predictable. Our goal is to discover what influences these natural DNA repair systems and how we can guide them to make gene editing more accurate. We are specifically looking at how certain 'histone modifications' in our cells affect DNA repair, using a new method to study many repair sites at once. By understanding these factors, we hope to develop better strategies for gene editing therapies.
Who could benefit from this research
Good fit: Patients with genetic diseases who might benefit from future gene editing therapies could find this foundational research relevant.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to more reliable and effective gene editing treatments for a wide range of genetic diseases.
How similar studies have performed: While CRISPR technology has shown promise, controlling the cell's natural DNA repair for precise gene editing remains a challenge that this work aims to address.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HESS, GAELEN T — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: HESS, GAELEN T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.