Making better protein-based medicines
Engineering protein developability
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-11117035
This work aims to create new ways to design and produce protein-based treatments that are more stable and effective for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11117035 on ClinicalTrials.gov |
What this research studies
Many protein-based medicines, like antibodies, are very helpful but can be difficult to develop because they might not be stable, dissolve well, or work as expected. This project focuses on creating more efficient methods to understand and improve how these proteins are made. By mapping out the best ways to engineer proteins, we hope to design new medicines that are more robust and easier to use. This will help speed up the process of discovering and developing new treatments for various conditions.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients, but future patients who could benefit from improved protein-based drugs, such as those needing antibody therapies, are the ultimate beneficiaries.
Not a fit: Patients who do not require protein-based therapies or those whose conditions are not treatable with such approaches may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more effective, stable, and readily available protein-based therapies for a wide range of diseases.
How similar studies have performed: While some methods exist, this project aims to develop a transformative platform for library-scale evaluation, suggesting a novel and more efficient approach than current experimental techniques.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HACKEL, BENJAMIN — UNIVERSITY OF MINNESOTA
- Study coordinator: HACKEL, BENJAMIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.