Making Alzheimer's clinical trials more inclusive using health records and explainable AI
Eligibility criteria design for Alzheimer's trials with real-world data and explainable AI
This project uses electronic health records and explainable artificial intelligence to design fairer eligibility rules so more typical people with Alzheimer's can take part in trials.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11237582 on NIH RePORTER |
What this research studies
If you have Alzheimer's, this project looks at real medical records from many patients like you and uses transparent AI to find which trial rules exclude common patients unnecessarily. The team will model how changing age limits, coexisting conditions, or medication restrictions would change who qualifies and whether safety signals appear. They will test revised criteria on real-world datasets and work with clinicians and regulators to make practical, safer eligibility rules that better match everyday patients.
Who could benefit from this research
Good fit: Ideal candidates to benefit are people with Alzheimer's disease whose age, other health conditions, or medications often exclude them from current trials.
Not a fit: People without Alzheimer's or those expecting direct treatment from the project rather than contributing data or informing future trial design are unlikely to receive direct medical benefit.
Why it matters
Potential benefit: If successful, this work could make Alzheimer's trials more representative and increase the chances that treatments proven in trials will help people seen in everyday care.
How similar studies have performed: Using real-world EHR data and AI to refine trial eligibility is an emerging approach with some promising early work but remains relatively new for Alzheimer's trials.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Wang, Fei — Weill Medical Coll of Cornell Univ
- Study coordinator: Wang, Fei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.