Machine learning to reduce unnecessary lab tests in the pediatric ICU

ML-ROVER: Machine Learning to Reduce Laboratory Test Overutilization

NIH-funded research University of Rochester · NIH-11144546

This project uses computer learning to help reduce unnecessary blood and lab tests for children in intensive care.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUniversity of Rochester NIH-funded
Lab location1 site (Rochester, United States)
Project IDNIH-11144546 on NIH RePORTER

What this research studies

Researchers will combine electronic health record data from multiple pediatric intensive care units to train machine-learning models that predict when common lab tests are likely unnecessary. They will focus on children because smaller blood volumes make repeated testing more likely to cause anemia and other harms. The team will design and build easy-to-use electronic decision-support tools with input from bedside clinicians and test them in staged phases. The goal is to reduce avoidable blood draws and improve safety and care quality for critically ill children.

Who could benefit from this research

Good fit: Children admitted to pediatric intensive care units who undergo frequent laboratory testing are the primary group who could be included or benefit.

Not a fit: Patients outside pediatric intensive care (for example adults) or children who require frequent tests for unstable conditions may not benefit from this work.

Why it matters

Potential benefit: If successful, this could mean fewer unnecessary blood draws, less iatrogenic anemia, and safer care for children in intensive care.

How similar studies have performed: Some adult-focused machine-learning models have shown promise at reducing low-value testing, but such approaches are largely untested in children and rarely integrated into real-world clinical workflows.

Where this research is happening

Rochester, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.