Lung function imaging to lower lung side effects from radiation plus immunotherapy
Quantitative Lung Function Imaging to Reduce Toxicity for patients treated with Radiation and Immunotherapy
This project uses CT-based lung function maps to guide radiation planning for people with lung cancer who are getting immunotherapy so they may have fewer lung side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11189626 on NIH RePORTER |
What this research studies
You would have lung motion data from routine 4DCT scans processed with special software to create maps showing which parts of your lung are working best. Those maps are used to design a personalized radiation plan that deliberately spares the most functional lung tissue. The approach aims to reduce overlapping lung toxicity (pneumonitis) that can come from combining radiotherapy and immunotherapy. If successful, the method could allow safer use of more effective combined treatments while protecting breathing and quality of life.
Who could benefit from this research
Good fit: People with lung cancer who are planned to receive thoracic radiotherapy together with immunotherapy are the most likely candidates for participation.
Not a fit: Patients not receiving thoracic radiation or immunotherapy, or those with very diffuse or end-stage lung disease that cannot be spared by planning, are unlikely to benefit from this approach.
Why it matters
Potential benefit: Could reduce rates of pneumonitis and breathing problems after combined radiation and immunotherapy, improving quality of life.
How similar studies have performed: Prior pilot work on imaging-based functional avoidance has shown promise in lowering radiation lung toxicity, but combining this approach specifically with immunotherapy is relatively new.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Vinogradskiy, Yevgeniy — Thomas Jefferson University
- Study coordinator: Vinogradskiy, Yevgeniy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.