Lung cancer tissue analysis and tumor model resource
Models, Profiling and Pathology Core
This project analyzes lung tumor and blood samples and creates patient-derived tumor models to help people with lung cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11265095 on NIH RePORTER |
What this research studies
If I take part, the team collects my lung tumor tissue, biopsy samples, and blood plasma under MSK IRB-approved protocols. They examine the tissue with pathology methods like immunohistochemistry and in situ hybridization and perform tumor DNA and RNA sequencing using MSK-IMPACT and a targeted cfDNA panel. They also grow patient-derived xenografts (PDXs) in mice to study how tumors behave and respond to treatments. The core links detailed pathology with genomic data and shares models and findings with researchers to help guide future treatments and trials.
Who could benefit from this research
Good fit: Ideal candidates are people with lung cancer treated at or willing to provide tissue and blood samples to Memorial Sloan Kettering who consent to genomic testing and specimen use.
Not a fit: People without lung cancer or those who cannot or will not provide tissue or blood samples are unlikely to directly benefit from this core.
Why it matters
Potential benefit: This work could improve how patients are matched to targeted therapies and accelerate development of new lung cancer treatments.
How similar studies have performed: Tumor sequencing, cfDNA profiling, and patient-derived xenografts are established approaches that have helped guide targeted therapy decisions and research, though PDXs mainly inform future treatments rather than provide immediate cures.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Ladanyi, Marc — Sloan-Kettering Inst Can Research
- Study coordinator: Ladanyi, Marc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.