LRP1's role in clearing amyloid and tau in Alzheimer's
Role of LRP1 in Alzheimer’s disease
Researchers want to find out whether the protein LRP1 in brain barrier cells helps move amyloid and tau out of the fluid around the brain in people with or at risk for Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11285491 on NIH RePORTER |
What this research studies
This project studies how LRP1 in the choroid plexus and tanycytes helps clear amyloid-beta and tau from cerebrospinal fluid into the blood. Scientists will use lab and animal models and tissue analyses to remove or alter LRP1 and watch how that changes protein clearance. They will also examine how LRP1 interacts with the leptin receptor and how diet-induced obesity affects clearance and memory. The goal is to link these mechanisms to Alzheimer’s-related accumulation of proteins.
Who could benefit from this research
Good fit: People with Alzheimer's disease, mild cognitive impairment, or those at increased risk who are willing to provide samples or participate in related observational efforts would be most relevant.
Not a fit: Patients seeking an immediate clinical therapy or those with non‑Alzheimer's dementias are unlikely to benefit directly from this basic-mechanism research.
Why it matters
Potential benefit: If successful, the work could point to new ways to boost removal of amyloid and tau and ultimately slow or prevent Alzheimer's progression.
How similar studies have performed: Prior laboratory and animal studies have linked LRP1 to amyloid clearance, but translating these findings into human treatments remains unproven.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Kim, Young-Bum — Beth Israel Deaconess Medical Center
- Study coordinator: Kim, Young-Bum
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.