Lowering blood pressure to prevent cognitive decline
Preventing Cognitive Decline by Reducing BP Target Trial (PCOT)
This study is looking at whether keeping blood pressure below 130/80 mm Hg can help prevent memory problems and dementia, and it's designed for people who want to see if new ways of managing blood pressure can lead to better brain health compared to regular care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10906225 on NIH RePORTER |
What this research studies
This research investigates how lowering blood pressure to less than 130/80 mm Hg can help prevent cognitive decline, including mild cognitive impairment and dementia. It utilizes a pragmatic clinical trial approach, embedding the study within health systems to assess the effectiveness of new blood pressure management strategies in real-world settings. Patients will receive team-based care and clinical decision support to monitor and manage their blood pressure effectively. The goal is to determine if these methods lead to better cognitive outcomes compared to standard care.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with high blood pressure, particularly those at risk for cognitive decline due to conditions like chronic kidney disease or diabetes.
Not a fit: Patients who do not have high blood pressure or those without risk factors for cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of cognitive decline and dementia in patients with high blood pressure.
How similar studies have performed: Previous studies, such as SPRINT and SPRINT-MIND, have shown that effective blood pressure control can reduce cognitive impairment, indicating a promising avenue for this research.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Vazquez, Miguel a — Ut Southwestern Medical Center
- Study coordinator: Vazquez, Miguel a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.