Low-load resistance training with blood flow restriction for people with advanced multiple sclerosis
Low-Load Resistance Training with Blood Flow Restriction in People with Multiple Sclerosis and Advanced Disability: A Randomized Control Trial
This study is looking at whether a special type of light weight training with added support can help veterans with advanced multiple sclerosis get stronger and move better, even if they usually feel too weak or tired for regular exercise.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10988223 on NIH RePORTER |
What this research studies
This research investigates the effects of low-load resistance training combined with blood flow restriction (BFR) on individuals with advanced multiple sclerosis (MS). The study aims to determine if this approach can improve muscle strength and mobility in patients who typically cannot engage in high-intensity exercise due to severe weakness and fatigue. Participants will undergo a controlled trial to assess the safety and effectiveness of this training method, which has shown promise in other populations. The research is particularly focused on veterans, who often experience more severe symptoms of MS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with advanced multiple sclerosis who experience significant muscle weakness and require assistance with mobility.
Not a fit: Patients with mild multiple sclerosis or those who do not experience significant mobility issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance muscle strength and mobility for patients with advanced MS, potentially improving their quality of life.
How similar studies have performed: Previous studies have shown that blood flow restriction combined with low-load resistance training can be effective in improving muscle strength in various populations, suggesting a promising avenue for this research.
Where this research is happening
Aurora, UNITED STATES
- VA Eastern Colorado Health Care System — Aurora, United States (Active)
Researchers
- Principal investigator: Manago, Mark M — VA Eastern Colorado Health Care System
- Study coordinator: Manago, Mark M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.