Low-dose aspirin after pregnancy high blood pressure to help blood vessels heal
Official title: Postpartum low-dose aspirin to augment vascular recovery following a hypertensive disorder of pregnancy
Funded at Women and Infants Hospital-Rhode Island · NIH-11185651 · Data updated 2026-11-12
People who had preeclampsia will take low-dose aspirin or a placebo after delivery to help blood vessels recover and lower blood pressure within six months.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Women and Infants Hospital-Rhode Island NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $172,223 |
| NIH project number | 5K23HL168356-03 |
| Project ID | NIH-11185651 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and over who recently experienced preeclampsia or another hypertensive disorder of pregnancy and are in the immediate postpartum period would be the intended participants.
✕Less likely to help
People who did not have a hypertensive disorder during pregnancy, those allergic to aspirin, with bleeding disorders, or already taking antiplatelet/anticoagulant medications are unlikely to benefit or may be ineligible.
What this research studies
You will be randomly assigned to take either low-dose aspirin or a placebo starting soon after delivery and continuing through the early postpartum period. This single-site pilot trial at Women and Infants Hospital will test whether running a randomized postpartum aspirin trial is feasible and safe. Researchers will measure blood vessel (endothelial) function and blood pressure, and compare results at six months after delivery between the aspirin and placebo groups. The study focuses on helping blood vessels recover in addition to routine blood pressure management after preeclampsia.
Why it matters
Potential benefit: If successful, postpartum low-dose aspirin could improve blood vessel healing and reduce blood pressure after preeclampsia, potentially lowering future cardiovascular risk.
How similar studies have gone: Low-dose aspirin is proven to help prevent preeclampsia during pregnancy, but using it after delivery to speed vascular recovery is a novel idea with limited prior clinical data.
Where this research is happening
-
Women and Infants Hospital-Rhode Island
Providence, United States Active
Researchers
- Principal investigator: Hauspurg, Alisse — Women and Infants Hospital-Rhode Island
- Study coordinator: Hauspurg, Alisse
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.