Low-dose aspirin after pregnancy high blood pressure to help blood vessels heal
Postpartum low-dose aspirin to augment vascular recovery following a hypertensive disorder of pregnancy
People who had preeclampsia will take low-dose aspirin or a placebo after delivery to help blood vessels recover and lower blood pressure within six months.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Women and Infants Hospital-Rhode Island NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-11185651 on NIH RePORTER |
What this research studies
You will be randomly assigned to take either low-dose aspirin or a placebo starting soon after delivery and continuing through the early postpartum period. This single-site pilot trial at Women and Infants Hospital will test whether running a randomized postpartum aspirin trial is feasible and safe. Researchers will measure blood vessel (endothelial) function and blood pressure, and compare results at six months after delivery between the aspirin and placebo groups. The study focuses on helping blood vessels recover in addition to routine blood pressure management after preeclampsia.
Who could benefit from this research
Good fit: Adults aged 21 and over who recently experienced preeclampsia or another hypertensive disorder of pregnancy and are in the immediate postpartum period would be the intended participants.
Not a fit: People who did not have a hypertensive disorder during pregnancy, those allergic to aspirin, with bleeding disorders, or already taking antiplatelet/anticoagulant medications are unlikely to benefit or may be ineligible.
Why it matters
Potential benefit: If successful, postpartum low-dose aspirin could improve blood vessel healing and reduce blood pressure after preeclampsia, potentially lowering future cardiovascular risk.
How similar studies have performed: Low-dose aspirin is proven to help prevent preeclampsia during pregnancy, but using it after delivery to speed vascular recovery is a novel idea with limited prior clinical data.
Where this research is happening
Providence, United States
- Women and Infants Hospital-Rhode Island — Providence, United States (Active)
Researchers
- Principal investigator: Hauspurg, Alisse — Women and Infants Hospital-Rhode Island
- Study coordinator: Hauspurg, Alisse
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.