Low-burden PrEP access through emergency rooms

ED2PrEP - patient focused, low-burden strategies for PrEP uptake among emergency departments patients: a cross-over hybrid implementation-effectiveness trial

NIH-funded research Albert Einstein College of Medicine · NIH-11098450

This project tries out easy, low-burden ways to help people at risk for HIV who come to emergency departments start and keep using PrEP.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionAlbert Einstein College of Medicine NIH-funded
Lab location1 site (Bronx, United States)
Project IDNIH-11098450 on NIH RePORTER

What this research studies

If you come to a participating Bronx emergency department for sexual health care or an STI, this project will offer one of two streamlined ways to learn about and get PrEP. The trial uses a crossover design where ED sites rotate between the two approaches so teams can compare which method helps more people start PrEP and stay linked to follow-up care. Approaches may include brief screening, on-the-spot counseling, same-day prescriptions or referrals, and low-burden follow-up support tailored to patients' needs. The work focuses on real-world delivery so successful practices could be adopted quickly across EDs.

Who could benefit from this research

Good fit: People at risk for HIV who are not currently on PrEP and who seek care for sexual health concerns or STIs in participating Bronx emergency departments.

Not a fit: People already taking PrEP, not at risk for HIV, or who do not visit the participating EDs are unlikely to benefit directly.

Why it matters

Potential benefit: If successful, the project could help more people at risk start PrEP quickly through EDs and reduce future HIV infections.

How similar studies have performed: Other pilot programs have shown emergency departments can initiate PrEP, but large pragmatic trials testing low-burden, scalable approaches are still limited.

Where this research is happening

Bronx, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.