Long-term health after leukemia in children with Down syndrome
Chronic Health Conditions in Survivors of Down Syndrome-Associated Leukemia
This project looks at ongoing medical and thinking problems in children with Down syndrome who had acute leukemia compared with children with Down syndrome who never had cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11125753 on NIH RePORTER |
What this research studies
You or your child would help researchers by sharing medical records, health history, and taking part in cognitive testing and questionnaires about daily health. The team will compare how common and how severe chronic health conditions are in Down syndrome survivors of childhood leukemia versus peers with Down syndrome but no cancer history. They will also look at thinking skills like attention and processing speed to see if treatment added extra challenges. The goal is to fill gaps because this group has often been left out of past research.
Who could benefit from this research
Good fit: Children and young adults with Down syndrome who were treated for acute leukemia in childhood, and their caregivers, who can share medical records and participate in testing or surveys are ideal candidates.
Not a fit: People without Down syndrome or individuals with Down syndrome who never had leukemia are unlikely to get direct benefits from findings specific to leukemia survivors.
Why it matters
Potential benefit: If successful, the work could lead to better follow-up care plans and support for people with Down syndrome who survived childhood leukemia.
How similar studies have performed: Very few prior studies have addressed late effects in this group and only small case series have looked at neuropsychological outcomes, so this work is relatively novel.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Gramatges, Maria Monica — Baylor College of Medicine
- Study coordinator: Gramatges, Maria Monica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.