Long-term formulation for a combination HIV treatment
Official title: Long-term formulation for combination antiviral treatment of HIV
Funded at Collaborations Pharmaceuticals, INC. · NIH-11256193 · Data updated 2026-11-12
A new antiviral drug combination for people living with HIV is being developed to stay effective against resistant virus strains.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Collaborations Pharmaceuticals, INC. NIH-funded |
| Lab location | 1 site (Fuquay Varina, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $306,870 |
| NIH project number | 1R43AI191982-01A1 |
| Project ID | NIH-11256193 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people living with HIV who may experience drug resistance or have limited options due to resistance to current therapies.
✕Less likely to help
Patients without HIV or those not facing drug resistance may not benefit from this research.
What this research studies
This project focuses on developing and testing a new class of anti-HIV compounds designed to work alongside existing drugs to overcome resistance. It builds on preclinical data, including how the drug is metabolized, how it behaves in the body, and its ability to reach the brain. The work includes in vitro tests of how the drug combines with an approved drug (cabotegravir) and how it might be cleared from the body. The goal is to advance promising compounds toward safer, more durable treatments for people with HIV.
Why it matters
Potential benefit: If successful, this work could lead to a new treatment option that remains effective against resistant HIV strains and helps maintain long-term viral suppression.
How similar studies have gone: Previous preclinical work on HIV drug resistance has identified promising compounds, but this specific approach is at an early stage.
Where this research is happening
-
Collaborations Pharmaceuticals, INC.
Fuquay Varina, United States Active
Researchers
- Principal investigator: Ekins, Sean — Collaborations Pharmaceuticals, INC.
- Study coordinator: Ekins, Sean
Related research
Other NIH-funded projects on the same topics.
-
Using machine learning to find new treatments for poisoning and Alzheimer's disease
This research uses computer intelligence to discover new medicines that can help people affected by certain types of poisoning and conditions like Alzheimer's disease.
-
Developing a treatment for CLN1 Batten Disease using enzyme replacement therapy
This study is testing a new treatment for young children with CLN1 Batten Disease by delivering a special enzyme directly into their brains to help improve their brain function and overall quality of life.
-
Using machine learning to find new treatments for acetylcholinesterase inhibition
This study is looking for new ways to find compounds that can help block a brain enzyme linked to Alzheimer's disease, with the hope of discovering better treatments for patients.
-
Developing a treatment for Nipah Virus infection
This study is looking at a potential new treatment for Nipah Virus using a medicine called pyronaridine, which has shown promise against other viruses, to see if it can help keep people safe and healthy if they get infected.
-
Using machine learning to predict how drugs interact with human transporters
This study is looking at how different medications work with proteins in our bodies that help move substances in and out of cells, with the goal of creating safer drugs that have fewer side effects and work better for specific organs.
-
Analyzing and visualizing data for predicting toxic effects of new molecules
This study is looking at how computer models can help predict if new chemicals or drugs might be harmful, making it easier and safer to test them before they reach patients like you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.