Long-term follow-up of type 1 diabetes treatments and complications
Epidemiology of Diabetes Interventions and Complications (EDIC) Study
Following people with type 1 diabetes who previously had intensive or standard blood-sugar treatment to learn how early care affects complications years later.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11379307 on NIH RePORTER |
What this research studies
You would join a long-term follow-up of participants from the original DCCT who received either intensive or conventional glucose control. Participants return periodically for medical exams, blood tests, imaging, and questionnaires to track eye, kidney, nerve, and heart health, and to provide DNA and other biological samples. The study uses standardized measurements and independent event review to link early treatment, genetics, and other risk factors with later complications. Past EDIC findings showed lasting benefits of early intensive control and the research continues to explore why those benefits persist and who remains at risk.
Who could benefit from this research
Good fit: Adults living with type 1 diabetes, especially those who had early intensive or conventional treatment and who can attend periodic clinic visits and testing, are ideal candidates.
Not a fit: People without type 1 diabetes or those unable to travel for follow-up visits are unlikely to benefit directly from participating.
Why it matters
Potential benefit: Could help doctors refine when and how to target blood-sugar control to prevent eye, kidney, nerve, and heart problems in people with type 1 diabetes.
How similar studies have performed: The original DCCT and prior EDIC work already showed that early intensive glucose control reduces long-term complications, so this is a continuation of a proven long-term follow-up approach.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Gubitosi-Klug, Rose a — Case Western Reserve University
- Study coordinator: Gubitosi-Klug, Rose a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.