Long-term follow-up of people with type 1 diabetes
Epidemiology of Diabetes Interventions and Complications (EDIC) Study
Following people with type 1 diabetes to see how their earlier treatments affect long-term risks of eye, kidney, nerve, and heart problems.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11143838 on NIH RePORTER |
What this research studies
If you joined, researchers follow adults who had type 1 diabetes (especially participants from the original DCCT) with regular visits, tests, and health record reviews over many years. They collect standardized measures of eye, kidney, nerve, and cardiovascular health plus blood samples for genetic and epigenetic analyses. Major health events are carefully documented and adjudicated by experts to ensure accurate outcome data. The study aims to understand how early glucose control influences health across decades.
Who could benefit from this research
Good fit: Ideal candidates are adults with a history of type 1 diabetes, particularly those who were part of the original DCCT cohort or are eligible for EDIC follow-up.
Not a fit: People without type 1 diabetes or those seeking an immediate new experimental therapy are unlikely to receive direct clinical benefit from this observational follow-up.
Why it matters
Potential benefit: Results could clarify how early treatment choices change long-term complication risks and help shape better care for people with type 1 diabetes.
How similar studies have performed: The original DCCT demonstrated that intensive early glucose control greatly reduced eye, kidney, and nerve complications, and EDIC has already shown lasting benefits (the 'metabolic memory' effect).
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Gubitosi-Klug, Rose a — Case Western Reserve University
- Study coordinator: Gubitosi-Klug, Rose a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.