Long-term follow-up of CREST-2 participants after carotid artery treatment
Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial
This follows people with carotid artery narrowing who had intensive medical care, with or without carotid surgery or stenting, to track strokes and vascular health over several more years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11191596 on NIH RePORTER |
What this research studies
If you were a CREST-2 participant, researchers will continue contact after the original trial ends using telephone and telehealth visits, review of your medical records, and occasional home health visits to check blood pressure, medications, and other risk factors. The extension keeps monitoring for strokes and other vascular events beyond the original 3–4 year window to see how outcomes change over a longer period. The team aims to use centralized processes to make follow-up efficient and consistent across participants. Data will be used to understand the real-world, long-term effects of intensive medical management alone versus medical management plus carotid procedures.
Who could benefit from this research
Good fit: Ideal candidates are people who previously enrolled in CREST-2 with carotid atherosclerotic disease, including those who received intensive medical management with or without endarterectomy or stenting.
Not a fit: People without carotid artery disease or those who never participated in CREST-2 would not be eligible and are unlikely to gain direct benefit from this extension.
Why it matters
Potential benefit: If successful, this could clarify whether long-term intensive medical care alone is as protective against stroke as adding carotid surgery or stenting, helping guide future treatment decisions.
How similar studies have performed: Earlier CREST and CREST-2 work improved risk-factor control and provided short-term safety data, but the question of long-term benefit of revascularization versus intensive medical therapy remains unresolved.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Meschia, James F — Mayo Clinic Jacksonville
- Study coordinator: Meschia, James F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.