Long-term follow-up of adults with type 1 diabetes to track complications and heart health
Epidemiology of Diabetes Interventions and Complications (EDIC) Study
Following adults with type 1 diabetes to see how early tight blood sugar control affects eye, kidney, nerve, and heart problems over many years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11389957 on NIH RePORTER |
What this research studies
If you take part, researchers follow people who had type 1 diabetes and collect regular exams, lab tests, imaging, and questionnaires to track health over time. They use standardized tests and carefully review events like vision loss, kidney disease, nerve damage, and heart problems. The team also studies genetic and other biological markers to help explain why some people develop complications and others do not. This work continues long-term follow-up of an earlier group where early intensive glucose control showed lasting benefits.
Who could benefit from this research
Good fit: Adults with type 1 diabetes—particularly those who were part of the original DCCT or who can share long-term medical records and attend periodic follow-up visits—are the intended participants.
Not a fit: People who do not have type 1 diabetes (for example those with type 2 diabetes) or those unable to attend follow-up visits or provide medical history are unlikely to receive direct benefit from participating.
Why it matters
Potential benefit: This work could clarify how early blood sugar control prevents long-term complications and help shape better long-term care for people with type 1 diabetes.
How similar studies have performed: The original DCCT showed that early intensive glucose control substantially reduced eye, kidney, and nerve complications, and EDIC has already demonstrated lasting benefits, making this extended follow-up a continuation of prior successful work.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Gubitosi-Klug, Rose a — Case Western Reserve University
- Study coordinator: Gubitosi-Klug, Rose a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.