Long-term effects of sudden kidney failure
Long-term effects of acute renal failure
This project looks at how immune cells called Th17 and a high-salt diet change healing after sudden kidney injury to help people at risk of chronic kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11369041 on NIH RePORTER |
What this research studies
You would be hearing about research that focuses on how a type of immune cell called Th17 may drive ongoing kidney damage after an episode of sudden kidney injury. The team will examine how Th17 cells change during injury and repair, how IL-17 and the Orai1 calcium channel influence those cells, and how a high-salt diet alters their behavior. Work combines lab experiments on immune and kidney tissue with genetic or drug approaches to reduce IL-17/Orai1 activity and measurements of blood pressure and kidney function over time. The goal is to link immune cell activity to specific effects on kidney cells that lead from acute injury to chronic disease.
Who could benefit from this research
Good fit: People who recently experienced acute kidney injury or who are at high risk of progressing to chronic kidney disease would be most relevant to this research.
Not a fit: Patients without recent AKI or whose kidney problems are driven by causes unrelated to immune responses or salt sensitivity may not see direct benefit from these findings.
Why it matters
Potential benefit: If successful, this work could point to new ways to prevent acute kidney injury from progressing to long-term chronic kidney disease.
How similar studies have performed: Prior preclinical work reported that blocking IL-17 reduced AKI and CKD progression in models and identified Orai1 as important, but translation to people is still limited.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Basile, David P. — Indiana University Indianapolis
- Study coordinator: Basile, David P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.